Mike and his team of shadow warriors are working freelance on military operations. When Mike thinks he recognises a biochemical terrorist from his past they uncover a plot to attack Seattle. With Mike drugged with a slow poison that only terrorist Sarkisian can stop the team go out to stop the attack.

In the Antarctic, after an expedition with Dr. Davis McClaren, the sled dog trainer Jerry Shepherd has to leave the polar base with his colleagues due to the proximity of a heavy snow storm. He ties his dogs to be rescued after, but the mission is called-off and the dogs are left alone at their own fortune. For six months, Jerry tries to find a sponsor for a rescue mission while his dogs fight for survival.

While practicing motocross in Hawaii, Sean Jones witnesses the brutal murder of an important American prosecutor by the powerful mobster Eddie Kim. He is protected and persuaded by the FBI agent Neville Flynn to testify against Eddie in Los Angeles. They embark in the red-eye Flight 121 of Pacific Air, occupying the entire first-class. However, Eddie dispatches hundred of different species of snakes airborne with a time operated device in the luggage to release the snakes in the flight with the intent of crashing the plane. Neville and the passengers have to struggle with the snakes to survive.